PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 1471460

Malignant prolactinoma.

M Berezin·I Gutman·R Tadmor·A Horowitz·G Findler
View original source ↗Export metadata ↓

Abstract

Malignant prolactinoma is a rare entity and only a few cases have been published. The diagnostic criteria and the clinical course remain unclear. We present a case of malignant prolactinoma in a woman with a 30-year duration of the disease. In the terminal stage of the disease the prolactinoma metastasized to the left eye, the prolactin level reaching 196000 mU/l. Bromocriptine in high doses was not effective. The response to pergolide was good in the first two years of treatment; thereafter an escape effect was observed. The patient died in a comatose state. A review of previously published cases follows.

Explore related subjects

BromocriptineCombined Modality TherapyFemaleHumansMiddle AgedOrbital NeoplasmsPergolidePituitary NeoplasmsProlactinProlactinomaCase ReportsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

M Berezin, I Gutman, R Tadmor, A Horowitz, G Findler. 1992. Malignant prolactinoma.. https://doi.org/10.1530/acta.0.1270476

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

Cytochrome P450 (P450) 3A4, the major catalyst involved in human drug oxidation, displays substrate- and reaction-dependent homotropic and heterotropic cooperative behavior. Although several models have been proposed, these mainly rely on steady-state kinetics and do not provide information on the contribution of the individual steps of P450 catalytic cycle to the observed cooperativity. In this work, we focused on the kinetics of substrate binding, and the fluorescent properties of bromocriptine and alpha-naphthoflavone allowed analysis of an initial ligand-P450 3A4 interaction that does not cause a perturbation of the heme spectrum. The binding stoichiometry for bromocriptine was determined to be unity using isothermal titration calorimetry and equilibrium dialysis methods, suggesting that the ligand bound to the peripheral site during the initial encounter dissociates subsequently. A three-step substrate binding model is proposed, based on absorbance and fluorescence stopped-flow kinetic data and equilibrium binding data obtained with bromocriptine, and evaluated using kinetic modeling. The results are consistent with the substrate molecule binding at a site peripheral to the active site and subsequently moving toward the active site to bind to the heme and resulting in a low to high spin iron shift. The last step is attributed to a conformational change in the enzyme active site. The later steps of binding were shown to have rate constants comparable with the subsequent steps of the catalytic cycle. The P450 3A4 binding process is more complex than a two-state system, and the overlap of rates of some of the events with subsequent steps is proposed to underlie the observed cooperativity.

Bromocriptine↗
PubMed2006

[A cocaine-induced variant of the neuroleptic malignant syndrome. A case study].

In this article we discuss the case of a patient with schizophrenia who presented with the clinical symptoms ofcoma, fever and rigidity. Initially it was suspected that the patient had a neuroleptic malignant syndrome. Closer inspection revealed that the patient had recently used cocaine. It is known that cocaine can cause a variant of the neuroleptic malignant syndrome. The patient was treated with dantrolene sodium and bromocriptine in the Intensive Care Unit and made a complete recovery within four days.

Bromocriptine↗