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Decrease of beta-cells and increase of alpha-cells in a diabetic patient with mitochondrial DNA 3243 (A-->G) mutation.

Toshihiro Kojima·Mayumi Yamamoto·Naoki Furuhashi·Hiroshi Sarui·Hisato Takatsu·Noriyuki Takeda·Tatsuo Ishizuka·Koji Yamada·Keigo Yasuda
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Abstract

We report here a case of a 53-year-old woman with mitochondrial 3243 (A-->G) mutation diabetes. Diabetes mellitus was diagnosed at 39 years of age. At 50 years of age, cardiomyopathy and hypothyroidism were noted. At 53 years of age, the patient was admitted to our hospital for treatment of necrotic ulceration of toes. However, she died of massive heart failure. Pathological examination at autopsy showed a decrease in size, number, and acidophilicity of islets in the pancreas. Immunohistochemical stain revealed a decrease in the beta-cell population to 20.5+/-9.2% and a relative increase in alpha-cell population to 48.6+/-11.5%.

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Cardiomyopathy, DilatedDNA, MitochondrialDeafnessDiabetes MellitusFatal OutcomeFemaleHumansHypothyroidismImmunohistochemistryIslets of LangerhansMiddle AgedPoint MutationRNA, Transfer, LeuCase ReportsJournal Article

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Toshihiro Kojima, Mayumi Yamamoto, Naoki Furuhashi, Hiroshi Sarui, Hisato Takatsu, Noriyuki Takeda, Tatsuo Ishizuka, Koji Yamada, Keigo Yasuda. 2003. Decrease of beta-cells and increase of alpha-cells in a diabetic patient with mitochondrial DNA 3243 (A-->G) mutation.. https://doi.org/10.2169/internalmedicine.42.1193

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