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PubMed · 14719721

Spinal analgesics.

Hollie Nguyen·Jason E Garber·Samuel J Hassenbusch
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Abstract

The important issues to be emphasized when considering the intrathecal administration of novel analgesics are their proven antinociceptive effect, safety (short- and long-term effects on the spinal cord and potential toxicities), stability in shelf solution and at body temperature by itself, or in combination with other drugs in spinal fluid, compatibility with a long-term spinal infusion pump, whether they are of sufficiently high potency and solubility to be used in the finite volume of an implanted infusion pump, and if a pharmaceutical company is willing to invest the immense resources needed for US Food and Drug Administration approval and subsequent commercial development.

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AnalgesicsHumansInjections, SpinalPainJournal ArticleReview

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BibTeXRIS

Hollie Nguyen, Jason E Garber, Samuel J Hassenbusch. 2003. Spinal analgesics.. https://doi.org/10.1016/s0889-8537(03)00091-9

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