Bmi1, stem cells, and senescence regulation.

In-Kyung Park; Sean J Morrison; Michael F Clarke

doi:10.1172/jci20800

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Bmi1, stem cells, and senescence regulation.

In-Kyung Park·Sean J Morrison·Michael F Clarke

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Abstract

Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.

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Animals Cell Line Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Gene Expression Regulation Humans Mice Models, Biological Mutation Nuclear Proteins Polycomb Repressive Complex 1 Proto-Oncogene Proteins Repressor Proteins Stem Cells Tumor Suppressor Protein p14ARF Journal Article Review

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In-Kyung Park, Sean J Morrison, Michael F Clarke. 2004. Bmi1, stem cells, and senescence regulation.. https://doi.org/10.1172/jci20800

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