Mammalian cell cycles without cyclin E-CDK2.

Qunyan Yu; Piotr Sicinski

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PubMed · 14726682

Mammalian cell cycles without cyclin E-CDK2.

Qunyan Yu·Piotr Sicinski

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Abstract

The family of mammalian E-type cyclins is composed of two proteins, termed cyclin E1 and E2. These two cyclins are widely expressed in proliferating cells. E-cyclins bind and activate cyclin dependent kinase CDK2. Cyclin E-CDK2 complexes were believed to play critical function in driving cell cycle progression of normal, nontransformed cells and of cancer cells. Several recent reports challenge this notion.

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Animals CDC2-CDC28 Kinases Cell Cycle Cyclin E Cyclin-Dependent Kinase 2 Embryo, Mammalian Gene Deletion Mice Journal Article Research Support, U.S. Gov't, P.H.S.

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Qunyan Yu, Piotr Sicinski. 2004-03-01. Mammalian cell cycles without cyclin E-CDK2.. https://pubmed.ncbi.nlm.nih.gov/14726682/

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