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Cell cycle control: a complex issue.

Nancy Olashaw·Tapan K Bagui·W J Pledger
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Abstract

Do p27Kip1 and p21Cip1 function as activators or inhibitors of D cyclin-cdk4 activity? Attempts to answer this question, and thus to understand how cdk4--a key cell cycle regulator--becomes active, have produced conflicting data. In this perspective, we summarize the results of studies addressing the effects of p27Kip1 and p21Cip1 on the assembly and activation of D cyclin-cdk4 complexes. Emphasis is placed on our experimental findings that support a model of cell cycle control in which p27Kip1 and p21Cip1 stabilize D cyclin-cdk4 complexes but inhibit D cyclin-cdk4 activity.

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AnimalsCell CycleCell Cycle ProteinsCyclin DCyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesCyclinsFibroblastsMiceProtein BindingProto-Oncogene ProteinsTumor Suppressor ProteinsJournal Article

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Nancy Olashaw, Tapan K Bagui, W J Pledger. 2004-03-01. Cell cycle control: a complex issue.. https://doi.org/10.4161/cc.3.3.721

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