HTTM, a horizontally transferred transmembrane domain.

Jörg Schultz

doi:10.1016/j.tibs.2003.11.002

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HTTM, a horizontally transferred transmembrane domain.

Jörg Schultz

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Abstract

Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is probably caused by horizontal gene transfer rather than by early evolution. The conservation of VKGC catalytic sites also indicates an enzymatic function for the other family members.

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Amino Acid Sequence Animals Carbon-Carbon Ligases Gene Transfer, Horizontal Humans Molecular Sequence Data Phylogeny Protein Structure, Tertiary Sequence Alignment Sequence Homology, Amino Acid Journal Article

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Jörg Schultz. 2004. HTTM, a horizontally transferred transmembrane domain.. https://doi.org/10.1016/j.tibs.2003.11.002

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