Indecent exposure: when telomeres become uncapped.

Miguel Godinho Ferreira; Kyle M Miller; Julia Promisel Cooper

doi:10.1016/s1097-2765(03)00531-8

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Indecent exposure: when telomeres become uncapped.

Miguel Godinho Ferreira·Kyle M Miller·Julia Promisel Cooper

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Abstract

The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.

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Animals Chromosome Aberrations DNA Damage Humans Models, Molecular Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins Telomerase Telomere Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Miguel Godinho Ferreira, Kyle M Miller, Julia Promisel Cooper. 2004-01-16. Indecent exposure: when telomeres become uncapped.. https://doi.org/10.1016/s1097-2765(03)00531-8

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