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PubMed · 14734120

In vivo antigen presentation.

Ronald N Germain·Marc K Jenkins
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Abstract

Monoclonal antibodies specific for defined peptide-MHC complexes are now being used to physically detect T-cell receptor ligands. These reagents have resulted in the identification of the cells that present antigen in lymphoid and non-lymphoid tissues after various forms of antigen administration. In addition, recent advances in real-time imaging technology have begun to measure the rate and directionality of T-cell movement relative to antigen-presenting cells in lymph nodes, shedding light on the earliest events in T-cell activation in a physiological setting.

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Adjuvants, ImmunologicAnimalsAntibodies, MonoclonalAntigen PresentationAntigen-Presenting CellsFlow CytometryHistocompatibility AntigensLymphoid TissueMicroscopy, FluorescenceReceptors, Antigen, T-CellT-LymphocytesJournal ArticleReview

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Ronald N Germain, Marc K Jenkins. 2004. In vivo antigen presentation.. https://doi.org/10.1016/j.coi.2003.11.001

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