Mammalian small molecule methyltransferases: their structural and functional features.

M Fujioka

doi:10.1016/0020-711x(92)90287-b

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Mammalian small molecule methyltransferases: their structural and functional features.

M Fujioka

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Abstract

Structural and functional features of mammalian S-adenosyl-methionine-dependent small molecule methyltransferases are reviewed. The methyltransferases have similar protomer molecular weights in the range of 25,000-35,000. Two common sequence motifs are found in all enzymes of known sequence. Whereas the kinetic mechanisms may be different, the methyltransferases in the free form bind S-adenosylmethionine. Most, if not all, of mammalian small molecule methyltransferases appear to have vicinal thiols in a catalytically important area of the enzyme.

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Amino Acid Sequence Animals Humans Methyltransferases Molecular Sequence Data S-Adenosylmethionine Sequence Homology, Amino Acid Journal Article Review

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M Fujioka. 1992. Mammalian small molecule methyltransferases: their structural and functional features.. https://doi.org/10.1016/0020-711x(92)90287-b

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