The complement system in xenotransplantation.

A P Dalmasso

doi:10.1016/0162-3109(92)90020-d

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The complement system in xenotransplantation.

A P Dalmasso

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Abstract

The immediate barrier to xenotransplantation across phylogenetically distant species, a manifestation of natural immunity, is hyperacute rejection of the xenograft. Complement (C) plays a central pathophysiological role in hyperacute rejection. Hyperacute rejection is initiated when C is activated by natural antibodies against the vascular endothelium of the transplanted organ or by the endothelium itself. C activation fragments alone or in conjunction with natural antibodies set in motion a series of events in the vasculature of the xenogeneic organ which result in loss of endothelial functional integrity and fibrin deposition. This article reviews recent findings concerning the role of C in hyperacute rejection and evidence suggesting that inhibition of C activation may be a critical approach to avert hyperacute rejection.

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Animals Complement Activation Complement Inactivator Proteins Complement Pathway, Alternative Complement Pathway, Classical Complement System Proteins Endothelium, Vascular Fibrin Graft Rejection Humans Transplantation, Heterologous Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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A P Dalmasso. The complement system in xenotransplantation.. https://doi.org/10.1016/0162-3109(92)90020-d

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