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PubMed · 14742571

Needle-free skin patch vaccination method for anthrax.

Gary R Matyas·Arthur M Friedlander·Gregory M Glenn·Stephen Little·Jianmei Yu·Carl R Alving
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Abstract

Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.

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Adjuvants, ImmunologicAdministration, CutaneousAnimalsAnthrax VaccinesAntibodies, BacterialAntigens, BacterialBacterial ToxinsEnterotoxinsEscherichia coli ProteinsFemaleMiceVaccinationVaccines, SyntheticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Gary R Matyas, Arthur M Friedlander, Gregory M Glenn, Stephen Little, Jianmei Yu, Carl R Alving. 2004. Needle-free skin patch vaccination method for anthrax.. https://doi.org/10.1128/iai.72.2.1181-1183.2004

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