Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension.

Robert Rejdak; Konrad Kohler; Tomasz Kocki; Yana Shenk; Waldemar A Turski; Etsuo Okuno; Cristiana Lehaci; Zbigniew Zagorski; Eberhart Zrenner; Frank Schuettauf

doi:10.1016/j.visres.2003.11.003

PubMed · 14751550

Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension.

Robert Rejdak·Konrad Kohler·Tomasz Kocki·Yana Shenk·Waldemar A Turski·Etsuo Okuno·Cristiana Lehaci·Zbigniew Zagorski·Eberhart Zrenner·Frank Schuettauf

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Abstract

The study examines age-dependent changes of kynurenic acid (KYNA) content and kynurenine aminotransferases (KAT I and KAT II) celluar expression in the retinas of DBA/2J mice. Retinas were obtained from DBA/2J mice of different ages (3, 6 and 11 months). C57BL6 mice were used as controls. As measured with HPLC, KYNA content decreased (p < 0.01) in the retinas of 6-month-old DBA/2J mice and continued to decrease (p < 0.0074) in the retinas of 11-month-old animals compared to the controls. Immunohistochemistry showed that expression of both KAT I and KAT II decreased markedly in the retinas of 11-month-old DBA/2J mice compared to controls. The impairment in KYNA biosynthesis in the retinas of DBA/2J mice may be one of the mechanisms of retinal neurodegeneration related to ocular hypertension.

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Aging Animals Chromatography, High Pressure Liquid Female Immunohistochemistry Kynurenic Acid Mice Mice, Inbred C57BL Mice, Inbred DBA Models, Animal Ocular Hypertension Retina Transaminases Journal Article Research Support, Non-U.S. Gov't

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Robert Rejdak, Konrad Kohler, Tomasz Kocki, Yana Shenk, Waldemar A Turski, Etsuo Okuno, Cristiana Lehaci, Zbigniew Zagorski, Eberhart Zrenner, Frank Schuettauf. 2004. Age-dependent decrease of retinal kynurenate and kynurenine aminotransferases in DBA/2J mice, a model of ocular hypertension.. https://doi.org/10.1016/j.visres.2003.11.003

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