Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography-mass spectrometry.

Stefan Weigel; Roland Kallenborn; Heinrich Hühnerfuss

doi:10.1016/j.chroma.2003.10.036

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Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography-mass spectrometry.

Stefan Weigel·Roland Kallenborn·Heinrich Hühnerfuss

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Abstract

Seven polymeric solid-phase extraction (SPE) sorbents were evaluated with regard to their ability to extract acidic, neutral and basic pharmaceuticals and estrogens simultaneously from water at neutral pH. Highest recoveries (70-100%) for the majority of the analytes were obtained with styrene-methacrylate and styrene-N-vinylpyrrolidone co-polymers. The latter one (Oasis HLB) was chosen for further refinement of an extraction method for the quantitative determination of acidic and neutral drugs in surface water samples at detection limits below 1 ng/l. A sequential elution protocol was applied for clean-up and separation of the extracted analytes into fractions suitable for further compound specific processing. The neutral analytes as well as the acidic compounds after derivatisation were quantified by GC-MS. Caffeine, ibuprofen, its metabolites and diclofenac were detected in river water samples in the 1-100 ng/l range.

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Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Hydrogen-Ion Concentration Journal Article Research Support, Non-U.S. Gov't

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Stefan Weigel, Roland Kallenborn, Heinrich Hühnerfuss. 2004-01-16. Simultaneous solid-phase extraction of acidic, neutral and basic pharmaceuticals from aqueous samples at ambient (neutral) pH and their determination by gas chromatography-mass spectrometry.. https://doi.org/10.1016/j.chroma.2003.10.036

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