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PubMed · 14754396

Dendritic cell endothelium interaction in autoimmunity.

C L Schlichting·W D Schareck·M Weis
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Abstract

Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.

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AnimalsAutoimmune DiseasesCell MovementDendritic CellsEndothelium, VascularHumansLymphoid TissueJournal ArticleReview

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C L Schlichting, W D Schareck, M Weis. 2004. Dendritic cell endothelium interaction in autoimmunity.. https://doi.org/10.2174/1381612043453397

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