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Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers.

M E Davis·S H Pun·N C Bellocq·T M Reineke·S R Popielarski·S Mishra·J D Heidel
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Abstract

Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have designed and prepared a tunable, non-viral nucleic acid delivery system that self-assembles with nucleic acids and centers around a new class of polymeric materials; namely, linear, water-soluble cyclodextrin-containing polymers. The relationships between polymer structure and gene delivery are illustrated, and the roles of the cyclodextrin moieties for minimizing toxicity and forming inclusion complexes in the self-assembly processes are highlighted. This vehicle is the first example of a polymer-based gene delivery system formed entirely by self-assembly.

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AnimalsCelluloseCyclodextrinsDrug CarriersNucleic AcidsSolubilityWaterJournal ArticleReview

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M E Davis, S H Pun, N C Bellocq, T M Reineke, S R Popielarski, S Mishra, J D Heidel. 2004. Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers.. https://doi.org/10.2174/0929867043456179

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