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PubMed · 14758772

Leptin-based immune intervention: current status and future directions.

Antonio La Cava·Giuseppe Matarese·Fanny M Ebling·Bevra H Hahn
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Abstract

Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. More specifically, leptin links nutritional status and energy balance to regulation of pro-inflammatory T-helper 1 immune responses. This has prompted several studies of targeted intervention with leptin antagonists in rodents to suppress onset and/or progression of chronic inflammation and autoimmunity. This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions.

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AnimalsAutoimmune DiseasesHumansInflammationLeptinNutritional StatusReceptors, Cell SurfaceReceptors, LeptinSignal TransductionT-LymphocytesJournal ArticleReview

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Antonio La Cava, Giuseppe Matarese, Fanny M Ebling, Bevra H Hahn. 2003. Leptin-based immune intervention: current status and future directions.. https://pubmed.ncbi.nlm.nih.gov/14758772/

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