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PubMed · 14761299

Global genetic analysis.

Elahe Elahi·Jochen Kumm·Mostafa Ronaghi
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Abstract

The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to be most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.

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AnimalsBiomarkersChromosome MappingGenetic Diseases, InbornGenetic LinkageGenetic Predisposition to DiseaseGenetic TechniquesGenetic TestingGenetic VariationGenome, HumanGenotypeHomozygoteHumansModels, BiologicalMutationPharmacogeneticsPolymorphism, Single NucleotideSequence Analysis, DNAJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Elahe Elahi, Jochen Kumm, Mostafa Ronaghi. 2004-01-31. Global genetic analysis.. https://doi.org/10.5483/bmbrep.2004.37.1.011

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