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AmpliBASE MT: a Mycobacterium tuberculosis diversity knowledgebase.

Ahmed A Majeed·Niyaz Ahmed·K Rajender Rao·S Ghousunnissa·Farhana Kauser·Buddhaditta Bose·H A Nagarajaram·V M Katoch·Debby V Cousins·Leonardo A Sechi·Robert H Gilman·Seyed E Hasnain
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Abstract

AmpliBASE MT is an online databank of high-resolution DNA fingerprints representing fluorescent amplified fragment length polymorphism (FAFLP) profiles or amplitypes developed for the Mycobacterium tuberculosis complex strains from 48 different countries. AmpliBASE MT is based on a relational database management system that is hyperlinked to visualize genotyping results in the form of DNA fingerprint images for individual strains. A flexible search system based on systematic comparisons of fragment sizes in base pairs allows inter-laboratory comparison of FAFLP profiles. Besides this, the database also displays previously published data on IS6110 profiles, spoligotypes, MIRU-VNTRs and large sequence polymorphisms along with the FAFLP records that will give the overall comparisons. Being the first of its kind, AmpliBASE MT is expected to be a very helpful tool in strengthening the concept of 'geographic genomics' and will be very helpful to molecular epidemiologists and those interested in diagnostic development for tuberculosis.

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DNA FingerprintingDatabase Management SystemsDatabases, Nucleic AcidGene Expression ProfilingGenetic VariationInformation Storage and RetrievalInternetMycobacterium tuberculosisPhenotypeSoftwareUser-Computer InterfaceJournal ArticleResearch Support, Non-U.S. Gov't

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Ahmed A Majeed, Niyaz Ahmed, K Rajender Rao, S Ghousunnissa, Farhana Kauser, Buddhaditta Bose, H A Nagarajaram, V M Katoch, Debby V Cousins, Leonardo A Sechi, Robert H Gilman, Seyed E Hasnain. 2004-02-05. AmpliBASE MT: a Mycobacterium tuberculosis diversity knowledgebase.. https://doi.org/10.1093/bioinformatics%2Fbth051

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