Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity.

Jakob C Mueller; Christophe Andreoli

doi:10.1093/bioinformatics/btg481

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Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity.

Jakob C Mueller·Christophe Andreoli

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Abstract

UNLABELLED: Association studies may request more details of a specific haplotype. Haplotype-specific decay of linkage disequilibrium is such a crucial and versatile characteristic. It may be used, e.g. to search for signals of natural selection in a risk haplotype. Here, we present a web-based tool to explore the relationship between population frequency and extended linkage disequilibrium measured as haplotype homozygosity of observed haplotypes within a specified candidate region. AVAILABILITY: The web-tool is available at http://ihg.gsf.de/cgi-bin/mueller/webehh.pl

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Algorithms Chromosome Mapping Computer Graphics Gene Expression Profiling Haplotypes Homozygote Internet Linkage Disequilibrium Pattern Recognition, Automated Sequence Analysis, DNA Software User-Computer Interface Evaluation Study Journal Article Research Support, Non-U.S. Gov't

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Jakob C Mueller, Christophe Andreoli. 2004-02-05. Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity.. https://doi.org/10.1093/bioinformatics%2Fbtg481

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