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Reduced thymocyte development in sonic hedgehog knockout embryos.

Divya K Shah·Ariadne L Hager-Theodorides·Susan V Outram·Susan E Ross·Alberto Varas·Tessa Crompton
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Abstract

The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.

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AnimalsCell DifferentiationCell DivisionDose-Response Relationship, ImmunologicDown-RegulationEmbryo, MammalianFemaleFetal Tissue TransplantationFetusHedgehog ProteinsLiver TransplantationMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutOrgan Culture TechniquesReceptors, Interleukin-2Signal TransductionT-Lymphocyte SubsetsThymus GlandTrans-ActivatorsJournal ArticleResearch Support, Non-U.S. Gov't

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Divya K Shah, Ariadne L Hager-Theodorides, Susan V Outram, Susan E Ross, Alberto Varas, Tessa Crompton. 2004-02-15. Reduced thymocyte development in sonic hedgehog knockout embryos.. https://doi.org/10.4049/jimmunol.172.4.2296

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