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The extrathymic T-cell development pathway.

B Rocha·P Vassalli·D Guy-Grand
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Abstract

In normal mice, not all T-lineage cells are generated and selected in the thymus; an alternative, extrathymic, development pathway exists. Extrathymic T cells are rare in the spleen and lymph nodes, but are abundant in some tissues, such as the gut. Here, Benedita Rocha, Pierre Vassalli and Delphine Guy-Grand discuss the rules of selection of extrathymic T cells, assess the possible role of these cells in the defence of epithelial integrity and their potential role in autoimmune disease.

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AnimalsAntigens, Differentiation, T-LymphocyteAutoimmune DiseasesCell DifferentiationLymphoid TissueMiceMice, NudeModels, BiologicalRatsRats, NudeReceptors, Antigen, T-CellSelection, GeneticT-Lymphocyte SubsetsJournal ArticleReview

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B Rocha, P Vassalli, D Guy-Grand. 1992. The extrathymic T-cell development pathway.. https://doi.org/10.1016/0167-5699(92)90074-h

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