PubMed · 14783664
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W S BULLOUGH. 1950. Mitotic activity and carcinogenesis.. https://doi.org/10.1038/bjc.1950.31
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DNA mutations lead to multiple defects of different control systems necessary to regulate cell growth, cell death and cell invasion, thus resulting in the development of a malignant tumor. While the loss of single control systems can still be compensated by others, the destruction of the whole network on a molecular level will cause tumor growth. Knowledge about these control systems and their defects during carcinogenesis may it possible to design new therapeutic strategies. Among them, gene therapy offers promising treatment options.
p21WAF1/CIP1 gene is known for a most important cell cycle regulator as well as its roles in appoptosis and differentiation. This review focuses on p21WAF1/CIP1 gene functions and its association with carcinogenesis. Better understanding of the structure and function of p21WAF1/CIP1 gene may help to comprehend molecular mechanisms of cancers and to facilitate diagnosis and treatment of malignancy.
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