[The hemins as active fermentative components].

We present a numerical method to identify possible candidates for quasi-stationary manifolds in complex reaction networks governed by systems of ordinary differential equations. Inspired by singular perturbation theory, we examine the ratios of certain components of the reaction rate vector. Those ratios that rapidly approach a nearly constant value define a slow manifold for the original flow in terms of quasi-integrals, that is, functions that are nearly constant along the trajectories. The dimensionality of the original system is thus effectively reduced without reliance on a priori knowledge of the different time scales in the system. We also demonstrate the relation of our approach to singular perturbation theory which, in its simplest form, is just the well-known quasi-steady-state approximation. In two case studies, we apply our method to oscillatory chemical systems: the 6-dimensional hemin-hydrogen peroxide-sulfite pH oscillator and a 10-dimensional mechanistic model for the peroxidase-oxidase (PO) reaction system. We conjecture that the presented method is especially suited for a straightforward reduction of higher dimensional dynamical systems where analytical methods fail to identify the different time scales associated with the slow invariant manifolds present in the system.

Hemin↗

PubMed2003

Coordination complex between haemin and parallel-quadruplexed d(TTAGGG).

Haemin, iron(III)-protoporphyrin IX complex, and parallel-quadruplexed d(TTAGGG) have been shown to form a stable coordination complex which exhibits spectroscopic properties remarkably similar to those of haemoproteins.

Hemin↗