PubMed · 14803237
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P S WYNE. 1951. Apocynum cannabinum.. https://pubmed.ncbi.nlm.nih.gov/14803237/
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OBJECTIVE: To study the flavonoids in the leaves of Apocynum ventum. METHOD: Compounds were separated by repeated polyacrylamide column chromatgraphy combined with Sephadex LH-20 column chromatgraphy, their structures were confirmed by the analysis of spectral data and physicochemical properties. RESULT: Six compounds were isolated from A. ventum. They were elucidated as quercetin (1), kaempferol (2), kaempferol-3-O-(6"-O-acetyl)-beta-D-glucopyranoside (3), quercetin-3-O-(6"-O-acetyl )-beta-D-glucopyranoside (4), quercetin-3-O-(6"-O-acetyl)-beta-D-galactopyranoside (5), kaempferol-7-O-alpha-L-rhamnopyranoside (6). CONCLUSION: Compound 5 and 6 were isolated from the genus Apocynum for the first time.
OBJECTIVE: To study the chemical constituents of the flowers of Apocynum venetum. METHOD: Chromatographic methods were used to isolate compounds from the flowers of A. venetum and spectral methods were used to identify the structures of the isolated compounds. RESULT: Seven compounds, kaempferol (I), quercetin (II), quercetin-3-O-beta-D-glucoside (III), kaempferol-3-O-beta-D-glucoside (IV), vanillic acid (V), baimaside (VI), daucosterol (III), were isolated from the flowers of A. venetum. CONCLUSION: Compound I, V, VI, VII were obtained from this plant for the first time.
Luobuma tea, prepared from the leaves of Apocynum venetum L., is a popular beverage in China. In this study, the activity of Luobuma leaf extract and its components against the formation of advanced glycation endproducts (AGEs), which are largely involved in the pathogenesis of diabetic vascular complications, was examined using the in vitro glycation reaction. Strong inhibitory activity against the formation of AGEs was shown by Luobuma aqueous extract. Following further fractionation of this extract, seven polyphenolic compounds, i.e. (+/-)-gallocatechin, (-)-epigallocatechin, (+/-)-catechin, (-)-epicatechin, epicatechin-(4beta-8)-gallocatechin, epigallocatechin-(4beta-8)-epicatechin and procyanidin B-2, were isolated by Sephadex LH-20 column chromatography. These purified compounds also exerted inhibitory activities that were more potent than the positive control, aminoguanidine. Our findings may help to explain the beneficial effects of this plant against atherosclerosis.