PubMed · 14827529
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R W SABATINI, T R MURROUGHS. 1951-03-22. Psycho-physiological visual processes.. https://pubmed.ncbi.nlm.nih.gov/14827529/
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We study light propagation in biological tissue containing an absorbing obstacle. In particular, we solve the infinite-domain problem in which an absorbing plate of negligible thickness prevents a portion of the light from the source from reaching the detector plane. Inasmuch as scattering in the medium is sharply peaked in the forward direction, we replace the governing radiative transport equation with the Fokker-Planck equation. The problem is solved first by application of the Kirchhoff approximation to determine the secondary source distribution over the surface of the plate. That result is propagated to the detector plane by use of Green's function. The Green's function is given as an expansion of plane-wave modes that are calculated numerically. The radiance is shown to obey Babinet's principle. Results from numerical computations that demonstrate this theory are shown.
Three-dimensional phosphorescence lifetime imaging is a novel method for the mapping of oxygen concentration in biological tissues. We present reconstruction techniques for recovering phosphorescent objects in highly scattering media based on the telegraph equation and two regularization methods, i.e., the Tikhonov-Phillips regularization and the maximum entropy method. Theoretical results are experimentally validated, and the reconstructed images of phosphorescent objects rendering oxygen maps in a layer are presented.
This article describes the Food and Drug Administration's recent manufacturing review experience with investigational new drug applications submitted for allogeneic pancreatic islets of Langerhans for the treatment of type 1 diabetes mellitus. In addition, considerations of islet preparation issues that will need to be resolved before the submission of a biologics license application are discussed.