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PubMed · 1483458

A weighting method for predicting protein structural class from amino acid composition.

G Zhou·X Xu·C T Zhang
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Abstract

A protein is generally classified into one of the following four structural classes: all alpha, all beta, alpha+beta and alpha/beta. In this paper, based on the weighting to the 20 constituent amino acids, a new method is proposed for predicting the structural class of a protein according to its amino acid composition. The 20 weighting parameters, which reflect the different properties of the 20 constituent amino acids, have been obtained from a training set of proteins through the linear-programming approach. The rate of correct prediction for a training set of proteins by means of the new method was 100%, whereas the highest rate of previous methods was 82.8%. Furthermore, the results showed that the more numerous training proteins, the more effective the new method.

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Amino AcidsMacromolecular SubstancesMathematicsModels, TheoreticalProtein ConformationProteinsX-Ray DiffractionJournal Article

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BibTeXRIS

G Zhou, X Xu, C T Zhang. 1992-12-15. A weighting method for predicting protein structural class from amino acid composition.. https://doi.org/10.1111/j.1432-1033.1992.tb17476.x

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