PubMed · 14853819
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L RIMBAUD, P PASSOUANT, G VALLAT. 1951-05-05. [Comatose encephalitis].. https://pubmed.ncbi.nlm.nih.gov/14853819/
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The various aspects of primary thyroid insufficiency are presented. Subclinical hypothyroidism is a special condition the prevalence of which is increasing. In the face of a growing concern of the population, subclinical hypothyroidism receives much attention from endocrinologists and internists but despite recent recommendations therapeutic strategies are not clear enough yet. The question of the feasibility of the systematic screening, at least in predisposed people, for hypothyroidism is under study. Overt hypothyroidism which is usually preceded by a long phase of subclinical hypothyroidism is therefore presentable if substitutive treatment is given early enough. Occasional patients, however, may rich the level of profound hypothyroidism unnoticed. The modalities of treatment of over hypothyroidism are described. Latrogenic hypothyroidism is also described. Finally, myxoedema coma is discussed not because its prevalence, which is very low, but because this condition may be forgotten.
Visual, somatosensory, and brainstem auditory evoked potentials provide functional quantitative assessment of the cerebral cortex and brainstem. Their contribution at the acute stage of coma concerns diagnosis, prognosis, and follow-up. Four patterns are observed in traumatic coma: pattern 1=dysfunction of the cerebral cortex, brainstem integrity: good prognosis in more than 80% of cases; pattern 2=midbrain dysfunction: prognosis depends on both the reversibility of midbrain dysfunction and the extent of associated axonal lesions in the hemispheric white matter; pattern 3=pontine dysfunction due to transtentorial herniation: ominous prognosis, this pattern must be early detected by continuous monitoring; pattern 4=brain death: we currently use evoked potentials at the only brain-death confirmatory test, even in sedated patients. The contribution of evoked potentials in vegetative or minimally responsive states concerns the identification of these patients whose state is determined by midbrain dysfunction and the evaluation of persisting cognitive abilities in individual cases.
The ethical and legal problems posed by severe outcome of coma are complex and their analysis requires a multi-disciplinary approach. Three aspects have been particularly studied in this paper. The first is a reminder of the medical definitions of the concepts of vegetative state and minimally conscious state. The second focuses on the analysis of the ethical and legal debate of these conditions at an international level. Finally, the third concerns the wealth prospects, proposed, in France, by the circular letter dated May 3, 2002.