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PubMed · 1485969

mRNA stability: in trans-it.

S W Peltz·A Jacobson
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Abstract

The regulation of mRNA stability is an important step in the control of gene expression. Characterization of the mechanisms involved in the turnover of individual mRNAs has identified a requirement for specific cis-acting sequences and trans-acting factors, as well as an involvement of the translation apparatus. In the past year, significant progress has been made in the identification of trans-acting factors by both biochemical and genetic approaches. This review summarizes that progress and promotes the notion that the ribosome itself should also be considered as a trans-acting component of the mRNA decay machinery.

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AnimalsEndoribonucleasesExoribonucleasesPoly AProtein BiosynthesisRNA, MessengerRNA-Binding ProteinsTrans-ActivatorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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S W Peltz, A Jacobson. 1992. mRNA stability: in trans-it.. https://doi.org/10.1016/0955-0674(92)90129-z

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