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PubMed · 14861374

A specific complement-fixation test for infection with poliomyelitis virus.

J CASALS·P K OLITSKY·R O ANSLOW
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Abstract

A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. Twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were positive and 6 of 22 from apparently normal persons having Lansing-neutralizing antibody, while this held true for only 1 of 19 from those having no Lansing-neutralizing antibody. The fact that positive results were found in sera from patients having an infection with poliomyelitis virus of the Brunhilde type and at the same time no Lansing-neutralizing antibody brings up the possibility of the existence of a cross-reaction in complement fixation between the two types.

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AnimalsAntibodies, NeutralizingComplement System ProteinsCross ReactionsImmunizationMicePan troglodytesPoliomyelitisVaccinationPOLIOMYELITISJournal Article

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J CASALS, P K OLITSKY, R O ANSLOW. 1951. A specific complement-fixation test for infection with poliomyelitis virus.. https://doi.org/10.1084/jem.94.2.123

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