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PubMed · 1490145

Mantle cell lymphoma: an update.

M Raffeld·C A Sander·T Yano·E S Jaffe
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Abstract

Mantle cell lymphoma is a distinctive pathologic entity that incorporates the previous histopathologic categories of centrocytic lymphoma and lymphocytic lymphoma of intermediate differentiation. These lymphomas are characterized by common histologic and immunologic characteristics that suggest derivation from the follicular mantle zone. Mantle cell lymphomas are characterized by the t(11;14) (q13;q32) translocation and its molecular counterpart bcl-1 rearrangement. This translocation activates a gene called BCL-1/PRAD-1. The identification of the BCL-1 gene product as a cyclin has added a new dimension to our understanding of the variety of mechanisms involved in lymphomagenesis.

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Antigens, CDAntigens, NeoplasmBiomarkers, TumorChromosomes, Human, Pair 11Chromosomes, Human, Pair 14CyclinsGene Expression Regulation, NeoplasticGene RearrangementHumansLymphoma, Non-HodgkinNeoplasm ProteinsReceptors, Antigen, B-CellTranslocation, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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M Raffeld, C A Sander, T Yano, E S Jaffe. 1992. Mantle cell lymphoma: an update.. https://doi.org/10.3109/10428199209054902

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