Gene expression in mental illness: a navigation chart to future progress.

S Matthysse; D L Levy; D Kinney; C Deutsch; C Lajonchere; D Yurgelun-Todd; B Woods; P S Holzman

doi:10.1016/0022-3956(92)90046-q

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Gene expression in mental illness: a navigation chart to future progress.

S Matthysse·D L Levy·D Kinney·C Deutsch·C Lajonchere·D Yurgelun-Todd·B Woods·P S Holzman

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Abstract

An initial course in disentangling complex causal interactions in psychiatric illnesses, we suggest, is finding co-familial traits with classical Mendelian segregation. Starting with non-Mendelian traits, three methods can be used to find underlying Mendelian phenotypes. (1) Statistically-inferred latent traits, with more nearly Mendelian transmission than the measures from which they are derived, can serve as pointers to concrete Mendelian phenotypes. (2) Linkage of non-Mendelian traits to genetic markers, if it can be established, can be followed by searching for phenotypes that discriminate carriers from non-carriers of the imputed trait gene. (3) In the long run, the most successful method is likely to be direct refinement of non-Mendelian behavioral and physiological traits into more fundamental components.

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Bipolar Disorder Chromosome Mapping Gene Expression Regulation Genetic Markers Humans Mental Disorders Models, Genetic Neuropsychological Tests Pedigree Risk Factors Schizophrenia Schizophrenic Psychology Journal Article Research Support, U.S. Gov't, P.H.S.

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S Matthysse, D L Levy, D Kinney, C Deutsch, C Lajonchere, D Yurgelun-Todd, B Woods, P S Holzman. 1992. Gene expression in mental illness: a navigation chart to future progress.. https://doi.org/10.1016/0022-3956(92)90046-q

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