The detachment cascade during metastasis.

C H van Aswegen; D J du Plessis

doi:10.1016/0306-9877(92)90063-i

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The detachment cascade during metastasis.

C H van Aswegen·D J du Plessis

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Abstract

The cause of detachment of tumour cells during metastasis is still one of the most intriguing questions of tumour propagation. A hypothesis is suggested herein for lysis of extracellular matrix that could ultimately lead to the detachment and spreading of malignant cells. According to this theory a certain optimal estrogen level initiates a series of enzymatic activations that culminate in detachment and spreading of tumour cells.

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Animals Cell Adhesion Collagen Collagenases Estrogens Fibrinolysin Growth Substances Humans Models, Biological Neoplasm Metastasis Plasminogen Prostaglandins Urokinase-Type Plasminogen Activator Journal Article

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C H van Aswegen, D J du Plessis. 1992. The detachment cascade during metastasis.. https://doi.org/10.1016/0306-9877(92)90063-i

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