Genetic Analysis Workshop II: study of Problem 2 linkage relationships by different methods.

F Demenais; P Darlu

doi:10.1002/gepi.1370010209

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Genetic Analysis Workshop II: study of Problem 2 linkage relationships by different methods.

F Demenais·P Darlu

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Abstract

Segregation and linkage analyse were performed on Problem 2 simulated data. Segregation analysis showed evidence for nearly recessive major susceptibility locus with parameter estimates close to the simulation input values. Linkage between this susceptibility locus (X) and the ten marker loci (A to J) led us to propose the following map: X-G-F-B.

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Chromosome Mapping Chromosome Segregation Computer Simulation Genes, Recessive Genetic Linkage Genetic Markers Genetic Predisposition to Disease Humans Likelihood Functions Models, Genetic Nuclear Family Odds Ratio Pedigree Penetrance Software Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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F Demenais, P Darlu. 1984. Genetic Analysis Workshop II: study of Problem 2 linkage relationships by different methods.. https://doi.org/10.1002/gepi.1370010209

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