Clean thoughts about dirty genes.

Russell N Van Gelder; John B Hogenesch

doi:10.1177/0748730403261123

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PubMed · 14964699

Clean thoughts about dirty genes.

Russell N Van Gelder·John B Hogenesch

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Abstract

The mouse has joined the fruit fly, bread mold, and cyanobacteria as a tractable genetic system for studying mechanisms of circadian rhythms. The circadian rhythms of "knock-out" mice for specific clock genes, however, have demonstrated significant variability between laboratories. In this brief review, the authors discuss possible sources of this variability, focusing particularly on questions of modifier loci of circadian rhythms that vary between inbred mouse strains. They conclude with a short list of recommendations for researchers working on circadian rhythms in mixed-strain mice.

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Animals Biological Clocks Circadian Rhythm Epistasis, Genetic Light Signal Transduction Mice Mice, Inbred Strains Mice, Knockout Reproducibility of Results Journal Article Review

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Russell N Van Gelder, John B Hogenesch. 2004. Clean thoughts about dirty genes.. https://doi.org/10.1177/0748730403261123

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