Glycans and neural cell interactions.

Ralf Kleene; Melitta Schachner

doi:10.1038/nrn1349

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PubMed · 14976519

Glycans and neural cell interactions.

Ralf Kleene·Melitta Schachner

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Abstract

Carbohydrate-carrying molecules in the nervous system have important roles during development, regeneration and synaptic plasticity. Carbohydrates mediate interactions between recognition molecules, thereby contributing to the formation of a complex molecular meshwork at the cell surface and in the extracellular matrix. The tremendous structural diversity of glycan chains allows for immense combinatorial possibilities that might underlie the fine-tuning of cell-cell and cell-matrix interactions.

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Amino Acid Sequence Animals Carbohydrate Conformation Carbohydrate Sequence Cell Communication Circadian Rhythm Extracellular Matrix Humans Molecular Sequence Data Nervous System Diseases Neural Cell Adhesion Molecules Neuronal Plasticity Neurons Polysaccharides Sequence Alignment Journal Article Research Support, Non-U.S. Gov't Review

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Ralf Kleene, Melitta Schachner. 2004. Glycans and neural cell interactions.. https://doi.org/10.1038/nrn1349

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