[Rosuvastatin: pharmacologic features].

Franco Bernini; Alberico L Catapano

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PubMed · 14983744

[Rosuvastatin: pharmacologic features].

Franco Bernini·Alberico L Catapano

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Abstract

The development of more active and safe new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) will increase the armamentarium of therapeutic tools available to the physicians for antiatherosclerotic therapies. Rosuvastatin presents a promising pharmacological profile: high affinity for the enzyme, a relative high hydrophilicity, selective hepatic uptake and activity, minimal cytochrome P450-mediated metabolism. Clinically the drug displays the highest lipid-lowering efficacy in the class with a safety profile similar to the other statins. Drug interaction potential is reduced. Rosuvastatin effectively decreases triglycerides, triglyceride-rich lipoproteins, non-HDL cholesterol, and increases HDL cholesterol. All together these properties will favor the achievement of therapeutic goals in the treated patients.

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Animals Arteriosclerosis Biotransformation Cholesterol Drug Interactions Fluorobenzenes Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypercholesterolemia Hyperlipidemias Hypolipidemic Agents Inflammation Pyrimidines Rosuvastatin Calcium Sulfonamides Triglycerides English Abstract Journal Article Review

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Franco Bernini, Alberico L Catapano. 2003. [Rosuvastatin: pharmacologic features].. https://pubmed.ncbi.nlm.nih.gov/14983744/

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