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PubMed · 14992013

[Progress in locked nucleic acid research].

Sheng-Mao Li·Xiang Xu·Hua-Ping Liang·Lei Li
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Abstract

Locked nucleic acid (LNA) is a novel oligonucleotide analogue in which 2'-O and 4'-C positions in the b-D-ribofuranosyl ring are joined via an O-methylene, S-methylene or amino-methylene moiety, locked in a C3'-endol3E north (N)-type furanose conformation. LNAs posses many properties, such as extraordinarily high hybridize affinities for complementary DNA/RNA sequences, remarkable antisense activity, nuclease resistance, good aqueous solubility and none detactable toxicity, et al. LNAs is a most promising molecule for development of diagnostics and therapeutics. For example, apply LNAs to single--nucleotide polymorphisms genotyping, telomerase activity have been efficiently suppressed by LNA oligomers, efficient cleavage of highly structured RNA has been achieved using LNA-modified DNAzymes (LNAzymes), and so on.

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AnimalsDNA, CatalyticHumansNucleic Acid ConformationOligonucleotidesOligonucleotides, AntisenseEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Sheng-Mao Li, Xiang Xu, Hua-Ping Liang, Lei Li. 2003. [Progress in locked nucleic acid research].. https://pubmed.ncbi.nlm.nih.gov/14992013/

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