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PubMed · 14998486

Ezrin...a metastatic detERMinant?

Marcello Curto·Andrea I McClatchey
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Abstract

The insidious process of tumor metastasis is the most devastating and least well-understood aspect of cancer. Metastasis is very complex and employs many cellular processes, suggesting that individual metastatic determinants may not be easily identified. Mounting evidence, culminating in the work described in two recent articles, strongly suggests that the membrane:cytoskeleton organizer Ezrin can promote tumor metastasis. Ultimately, a better understanding of exactly how Ezrin confers metastatic advantage will provide important insight into this key problem in cancer biology.

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Acute-Phase ProteinsAnimalsCell AdhesionCell DivisionCell MovementCell SurvivalCytoskeletal ProteinsCytoskeletonGene Expression ProfilingHepatocyte Growth FactorHumansMiceModels, AnimalNeoplasm InvasivenessNeoplasms, ExperimentalNeurofibromin 2OsteosarcomaPhosphoproteinsRNA, Small InterferingRhabdomyosarcomaEzrinJournal ArticleReview

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Marcello Curto, Andrea I McClatchey. 2004. Ezrin...a metastatic detERMinant?. https://doi.org/10.1016/s1535-6108(04)00031-5

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