Atomic force microscopy and drug discovery.

J Michael Edwardson; Robert M Henderson

doi:10.1016/s1359-6446(03)02905-2

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PubMed · 15012930

Atomic force microscopy and drug discovery.

J Michael Edwardson·Robert M Henderson

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Abstract

Atomic force microscopy is being used ever more widely in biological imaging, because of its unique ability to provide structural information at the single molecule level and under near-physiological conditions. Detailed topographic images of potential drug targets, such as proteins and DNA, have been produced, and the folding of modular proteins has been studied using single-molecule force spectroscopy. Recently, atomic force microscopy has been used to examine ligand-protein and ligand-DNA interactions, and to begin to determine the architecture of multi-subunit proteins, including a member of the superfamily of ionotropic receptors. Atomic force microscopy is fast becoming a valuable addition to the pharmaceutical industry's toolkit.

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DNA Drug Design Drug Industry Humans Intercalating Agents Ligands Membrane Proteins Microscopy, Atomic Force Pharmaceutical Preparations Journal Article Research Support, Non-U.S. Gov't Review

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J Michael Edwardson, Robert M Henderson. 2004-01-15. Atomic force microscopy and drug discovery.. https://doi.org/10.1016/s1359-6446(03)02905-2

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