A highly toxic morphine-3-glucuronide derivative.

Mariona Salvatella; Gemma Arsequell; Gregorio Valencia; Raquel E Rodríguez

doi:10.1016/j.bmcl.2003.12.016

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PubMed · 15012991

A highly toxic morphine-3-glucuronide derivative.

Mariona Salvatella·Gemma Arsequell·Gregorio Valencia·Raquel E Rodríguez

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Abstract

By the coupling of octylamine to the uronic acid function of morphine-3-glucuronide (M3G) a new glycoconjugate (morphine-3-octylglucuronamide, M3GOAM) was prepared. When assayed in both rats and mice up to ng/kg (i.p.) doses none of the animals survived. The aliphatic octyl chain may be the lethal factor since a closely related derivative (M3GNH2), was not toxic and showed similar opioid antagonist properties than naloxone.

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Animals Behavior, Animal Dose-Response Relationship, Drug Mice Molecular Structure Morphine Morphine Derivatives Naloxone Narcotic Antagonists Rats Receptors, Opioid Journal Article Research Support, Non-U.S. Gov't

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Mariona Salvatella, Gemma Arsequell, Gregorio Valencia, Raquel E Rodríguez. 2004-02-23. A highly toxic morphine-3-glucuronide derivative.. https://doi.org/10.1016/j.bmcl.2003.12.016

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