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PubMed · 15017001

Columnar architecture sculpted by GABA circuits in developing cat visual cortex.

Takao K Hensch·Michael P Stryker
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Abstract

The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic gamma-aminobutyric acid (GABA)-mediated inhibition with benzodiazepines. Local enhancement by agonist (diazepam) infusion did not perturb visual responsiveness, but did widen column spacing. An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity.

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AnimalsCarbolinesCatsDiazepamDominance, OcularElectrophysiologyGABA-A Receptor AgonistsNeural InhibitionNeuronsPhotic StimulationReceptors, GABA-ASynaptic TransmissionThalamusVision, OcularVisual CortexVisual Pathwaysgamma-Aminobutyric AcidJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Takao K Hensch, Michael P Stryker. 2004-03-12. Columnar architecture sculpted by GABA circuits in developing cat visual cortex.. https://doi.org/10.1126/science.1091031

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