T-cell anergy.

Fernando Macián; Sin-Hyeog Im; Francisco J García-Cózar; Anjana Rao

doi:10.1016/j.coi.2004.01.013

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PubMed · 15023415

T-cell anergy.

Fernando Macián·Sin-Hyeog Im·Francisco J García-Cózar·Anjana Rao

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Abstract

Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.

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Animals Clonal Anergy Dendritic Cells Receptors, Antigen, T-Cell Self Tolerance Signal Transduction T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Fernando Macián, Sin-Hyeog Im, Francisco J García-Cózar, Anjana Rao. 2004. T-cell anergy.. https://doi.org/10.1016/j.coi.2004.01.013

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