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PubMed · 15026051

Pi-delocalized beta-carbolinium cations as potential antimalarials.

Kiyosei Takasu·Tsubasa Shimogama·Chalerm Saiin·Hye-Sook Kim·Yusuke Wataya·Masataka Ihara
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Abstract

Several beta-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral beta-carbolines and a good correlation was observed between pi-delocalized lipophilic cationic structure and antimalarial efficacy.

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AnimalsAntimalarialsCarbolinesCationsPlasmodium falciparumJournal ArticleResearch Support, Non-U.S. Gov't

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Kiyosei Takasu, Tsubasa Shimogama, Chalerm Saiin, Hye-Sook Kim, Yusuke Wataya, Masataka Ihara. 2004-04-05. Pi-delocalized beta-carbolinium cations as potential antimalarials.. https://doi.org/10.1016/j.bmcl.2004.01.055

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