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Interferon-beta 1a and SARS coronavirus replication.

Lisa E Hensley·Lisa E Fritz·Peter B Jahrling·Christopher L Karp·John W Huggins·Thomas W Geisbert
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Abstract

A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made it a critical public health issue. Because no effective treatments are available, an intensive effort is under way to identify and test promising antiviral drugs. Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro.

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AnimalsAntiviral AgentsChlorocebus aethiopsCytopathogenic Effect, ViralHumansIn Vitro TechniquesInterferon Type IInterferon beta-1aInterferon-betaRecombinant ProteinsSevere acute respiratory syndrome-related coronavirusSevere Acute Respiratory SyndromeVero CellsVirus ReplicationJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Lisa E Hensley, Lisa E Fritz, Peter B Jahrling, Christopher L Karp, John W Huggins, Thomas W Geisbert. 2004. Interferon-beta 1a and SARS coronavirus replication.. https://doi.org/10.3201/eid1002.030482

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