Central memory and effector memory T cell subsets: function, generation, and maintenance.

Federica Sallusto; Jens Geginat; Antonio Lanzavecchia

doi:10.1146/annurev.immunol.22.012703.104702

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Central memory and effector memory T cell subsets: function, generation, and maintenance.

Federica Sallusto·Jens Geginat·Antonio Lanzavecchia

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Abstract

The memory T cell pool functions as a dynamic repository of antigen-experienced T lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that memory T lymphocytes contain distinct populations of central memory (TCM) and effector memory (TEM) cells characterized by distinct homing capacity and effector function. This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice.

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Animals Cell Differentiation Cell Movement Humans Immunologic Memory Signal Transduction T-Lymphocyte Subsets Th1 Cells Th2 Cells Journal Article Research Support, Non-U.S. Gov't Review

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Federica Sallusto, Jens Geginat, Antonio Lanzavecchia. 2004. Central memory and effector memory T cell subsets: function, generation, and maintenance.. https://doi.org/10.1146/annurev.immunol.22.012703.104702

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