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HIV-1 transgenic rats develop T cell abnormalities.

William Reid·Sayed Abdelwahab·Mariola Sadowska·David Huso·Ashley Neal·Aaron Ahearn·Joseph Bryant·Robert C Gallo·George K Lewis·Marvin Reitz
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Abstract

HIV-1 infection leads to impaired antigen-specific T cell proliferation, increased susceptibility of T cells to apoptosis, progressive impairment of T-helper 1 (Th1) responses, and altered maturation of HIV-1-specific memory cells. We have identified similar impairments in HIV-1 transgenic (Tg) rats. Tg rats developed an absolute reduction in CD4+ and CD8+ T cells able to produce IFN-gamma following activation and an increased susceptibility of T cells to activation-induced apoptosis. CD4+ and CD8+ effector/memory (CD45RC- CD62L-) pools were significantly smaller in Tg rats compared to non-Tg controls, although the converse was true for the naïve (CD45RC+ CD62L+) T cell pool. Our interpretation is that the HIV transgene causes defects in the development of T cell effector function and generation of specific effector/memory T cell subsets, and that activation-induced apoptosis may be an essential factor in this process.

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AnimalsAnimals, Genetically ModifiedApoptosisCD4-CD8 RatioHIV-1Interferon-gammaL-SelectinLeukocyte Common AntigensLymphocyte ActivationLymphocyte CountModels, AnimalRatsT-LymphocytesJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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William Reid, Sayed Abdelwahab, Mariola Sadowska, David Huso, Ashley Neal, Aaron Ahearn, Joseph Bryant, Robert C Gallo, George K Lewis, Marvin Reitz. 2004-03-30. HIV-1 transgenic rats develop T cell abnormalities.. https://doi.org/10.1016/j.virol.2003.12.010

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