Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age.

P Fattoretti; C Bertoni-Freddari; T Casoli; G Di Stefano; G Giorgetti; M Solazzi

doi:10.1196/annals.1299.092

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Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age.

P Fattoretti·C Bertoni-Freddari·T Casoli·G Di Stefano·G Giorgetti·M Solazzi

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Abstract

We measured the effect of chronic ethanol administration on the expression of Glut3 in the cerebellum and hippocampus of adult and old rats. Glut3 expression significantly decreased in aging, in ethanol-treated rats vs. age-matched controls, and in adult- vs. old ethanol-treated rats. These findings lend consistent support to the hypothesis that disturbances of glucose metabolism due to ethanol may constitute an unfavorable condition predisposing to neuronal death.

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Aging Animals Apoptosis Cerebellum Ethanol Glucose Transporter Type 3 Hippocampus Monosaccharide Transport Proteins Nerve Tissue Proteins Rats Journal Article

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P Fattoretti, C Bertoni-Freddari, T Casoli, G Di Stefano, G Giorgetti, M Solazzi. 2003. Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age.. https://doi.org/10.1196/annals.1299.092

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