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Reconciling the numbers: ESTs versus protein-coding genes.

Anton Nekrutenko
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Abstract

The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.

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AnimalsExpressed Sequence TagsGenome, HumanGenomicsHumansMiceOpen Reading FramesProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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Anton Nekrutenko. 2004-03-19. Reconciling the numbers: ESTs versus protein-coding genes.. https://doi.org/10.1093/molbev%2Fmsh125

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