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PubMed · 15034319

[HIV Antigens as complement fixing circulating immune complexes].

P Filippini·M Guarino·C Lapenta·C Marrocco·L Panico·V Messina·F Piccinino·E Sagnelli
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Abstract

To detect HIV antigens in circulating complement fixing immune complexes (ICs) we assessed an ELISA using wells of microtitre plates coated with F(ab)2 anti-C3b and monoclonal antibodies anti-HIV gp120 and anti-HIV p24. We tested 24 anti-HIV positive subjects (Group A), 10 anti-HIV negative subjects at risk of acquiring HIV infection (Group B), 20 normal controls (Group C) and 2 seroconversion panels. We found HIV antigens in ICs in all sera from seroconversion panels, in 25.5% of sera from subjects in Group A, in 28.6% of sera from subjects in Group B and in no serum from subjects in Group C. A subject in Group B acquired HIV infection during the observation. HIV antigens in ICs by our assay were detected 8 months before Anti-HIV and Ag by commercial ELISA.

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P Filippini, M Guarino, C Lapenta, C Marrocco, L Panico, V Messina, F Piccinino, E Sagnelli. 1997. [HIV Antigens as complement fixing circulating immune complexes].. https://pubmed.ncbi.nlm.nih.gov/15034319/

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